배아 및 조직 발달과정에서 세포의 운명 결정 기전연구
조직재생관련 줄기세포 증식 및 분화능의 분자적 조절기전 연구 및 미세환경 신호전달인 Sonic hedgehog과 Wnt 신호전달의 상호작용 연구
노화 및 퇴행성질환관련 줄기세포능 조절 및 섬유화와 같은 병태적 재생을 야기하는 기전 규명을 통하여 이를 제어할 수 있는 인자 발굴
대사성 질환의 분자적 조절 기전연구
학력
(박사) Albert-Ludwigs University Freiburg, Germany
약력/경력
2013-present Professor SKKU School of Medicine
2007-2013 Associate Professor SKKU School of Medicine
1994-1999 Assistant Professor Mount Sinai School of Medicine of New York University
1990-1994 Research Associate Mount Sinai School of Medicine of New York University
학술지 논문
(2024)
Prmt7 regulates the JAK/STAT/Socs3 signaling pathway in postmenopausal cardiomyopathy.
EXPERIMENTAL AND MOLECULAR MEDICINE.
56,
3
(2023)
<i>Inonotus obliquus</i> upregulates muscle regeneration and augments function through muscle oxidative metabolism.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES.
19,
15
(2021)
Role of Protein Arginine Methyltransferases and Inflammation in Muscle Pathophysiology.
FRONTIERS IN PHYSIOLOGY.
12,
712389
(2021)
Calbindin regulates Kv4.1 trafficking and excitability in dentate granule cells via CaMKII-dependent phosphorylation.
EXPERIMENTAL AND MOLECULAR MEDICINE.
53,
7
(2021)
Impaired pattern separation in Tg2576 mice is associated with hyperexcitable dentate gyrus caused by Kv4.1 downregulation.
MOLECULAR BRAIN.
14,
1
(2021)
BST204 Protects Dexamethasone-Induced Myotube Atrophy through the Upregulation of Myotube Formation and Mitochondrial Function.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH.
18,
5
(2020)
Cdo Is Required for Efficient Motor Neuron Generation of Embryonic Stem Cells.
INTERNATIONAL JOURNAL OF STEM CELLS.
13,
3
(2020)
Indoprofen prevents muscle wasting in aged mice through activation of PDK1/AKT pathway.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE.
11,
4
(2020)
Satellite cell-specific ablation of Cdon impairs integrin activation, FGF signalling, and muscle regeneration.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE.
11,
4
(2020)
ZNF746/PARIS overexpression induces cellular senescence through FoxO1/p21 axis activation in myoblasts.
CELL DEATH & DISEASE.
11,
5
(2020)
Ginsenoside Rb1 and Rb2 upregulate Akt/mTOR signaling-mediated muscular hypertrophy and myoblast differentiation.
JOURNAL OF GINSENG RESEARCH.
44,
3
(2020)
BST204, a Rg3 and Rh2 Enriched Ginseng Extract, Upregulates Myotube Formation and Mitochondrial Function in TNF-alpha-Induced Atrophic Myotubes.
AMERICAN JOURNAL OF CHINESE MEDICINE.
48,
3
(2020)
PRMT7 deficiency causes dysregulation of the HCN channels in the CA1 pyramidal cells and impairment of social behaviors.
EXPERIMENTAL AND MOLECULAR MEDICINE.
52,
4
(2020)
Kv4.1, a Key Ion Channel For Low Frequency Firing of Dentate Granule Cells, Is Crucial for Pattern Separation.
JOURNAL OF NEUROSCIENCE.
40,
11
(2020)
Prmt7 promotes myoblast differentiation via methylation of p38MAPK on arginine residue 70.
CELL DEATH AND DIFFERENTIATION.
27,
2
(2020)
PRMT7 methylates and suppresses GLI2 binding to SUFU thereby promoting its activation.
CELL DEATH AND DIFFERENTIATION.
27,
1
(2019)
Arginine methylation as a key post-translational modification in skeletal muscle homeostasis: a review.
Precision and Future Medicine.
3,
4
(2019)
Roles of ErbB3-binding protein 1 (EBP1) in embryonic development and gene-silencing control.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.
116,
49
(2019)
PRMT1 suppresses ATF4-mediated endoplasmic reticulum response in cardiomyocytes.
CELL DEATH & DISEASE.
10,
12
(2019)
Methylation determines the extracellular calcium sensitivity of the leak channel NALCN in hippocampal dentate granule cells.
EXPERIMENTAL AND MOLECULAR MEDICINE.
51,
10
특허/프로그램
Composition comprising farnesol and use thereof.
14/866,216.
20200922.
미국
Composition comprising farnesol and use thereof.
15186781.9.
20200506.
EU연합
진세노사이드 Rg1을 유효성분으로 포함하는 근육 재생용 조성물.
17-1193-_______.
20190730.
대한민국
에피카테킨을 유효성분으로 포함하는 오십견 및 근육암 예방 또는 치료용 약학적 조성물.
10-2016-0091901.
20180328.
대한민국
학술회의논문
(2020)
Muscle Aging and Neuromuscular Function.
AOCE-SICEM 2020.
대한민국
(2020)
Targeting Muscle Aging.
대한노인병학회 제 65차 학술대회(춘계).
대한민국
(2020)
Protein arginine methyltransferase 1 in control of cardiovascular function.
2020 KALAS (한국실험동물학회) International Symposium.
대한민국
(2020)
The control of muscle homeostasis and aging.
The 4th Young Leaders Camp.
대한민국
(2018)
Targeting muscle metabolism and aging.
제17회 백인제기념임상의학연구소 학술대회 -근감소증-.
대한민국
(2018)
Ginsenoside Rg1 augments oxidative metabolism and anabolic response of skeletal muscle in mice.
2018 ASCB Meeting.
미국
(2018)
Skeletal muscle specific PRMT1 deletion causes muscle atrophy via deregulation of PRMT6/FOXO3 axis.
2018 ASCB Meeting.
미국
(2018)
The inhibition of Cellular Chloride Channel 1 enhances Ca2+ and reactive oxygen species signaling in A549 human lung cancer cells.
2018 ASCB Meeting.
미국
(2018)
Targeting skeletal muscle metabolism and aging.
2018 퇴행성질환 연구사업 심포지움.
대한민국
(2018)
Targeting muscle metabolism and aging.
2018 대한골대사학회 제30차 추계학술대회.
대한민국
(2018)
Ex2 suppresses muscle wasting through PDK1/Akt activation augmenting muscle mass increase.
International Conference on Muscle Wasting-Molecular Mechanisms of Muscle Wasting during Aging and Disease.
스위스
(2018)
Wnt inhibitory factor-1 biding to a promyogenic receptor Cdo is critical for reciprocal modulation of Wnt signal and promyogenic kinases.
International Conference on Muscle Wasting-Molecular Mechanisms of Muscle Wasting during Aging and Disease.
스위스
(2018)
Skeletal muscle-specific PRMT1 deletion causes muscle atrophy via deregulation of PRMT6/FoxO3a axis.
International Conference on Muscle Wasting- Molecular Mechanisms of Muscle Wasting during Aging and Disease.
스위스
(2018)
The role of Cdon in the generation of embryonic stem cell-derived motor neuron.
International Conference on Muscle Wasting-Molecular Mechanisms of Muscle Wasting during Aging and Disease.
스위스
(2018)
A defective inactivation of a novel LQT-3 mutation with a selective efficacy of mexiletine treatment.
2018 International Conference: Korean Society for Molecular and Cellular Biology.
대한민국
(2018)
Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation.
2018 International Conference: Korean Society for Molecular and Cellular Biology.
대한민국
(2018)
Ginsenoside Rg1 augments oxidative metabolism and anabolic response of skeletal muscle in mice.
2018 International Conference: Korean Society for Molecular and Cellular Biology.
대한민국
(2018)
SGTb regulates a surface localization of a guidance receptor BOC to promote neurite outgrowth.
2018 International Conference: Korean Society for Molecular and Cellular Biology.
대한민국
(2018)
The role of PRMT7 in menopause-induced cardiovascular diseases.
2018 International Conference: Korean Society for Molecular and Cellular Biology.
대한민국
(2018)
Conditional deletion of Cdo in muscle stem cells results in defective muscle regeneration due to perturbed muscle stem cell function.
2018 International Conference: Korean Society for Molecular and Cellular Biology.
대한민국
